Clinical Trials

COMMANDS: A Phase 3 study of luspatercept (ACE-536) vs epoetin alfa for the treatment of anemia in patients with MDS

For patients with IPSS-R very-low-, low-, or intermediate-risk MDS dependent on red cell transfusions, the COMMANDS trial may be of interest for you.

The COMMANDS trial is a Phase 3 trial comparing a new treatment, luspatercept (ACE-536), against epoetin alfa in patients who have not taken erythropoiesis-stimulating agents (ESA) before.

Patients who qualify for this trial will be randomly assigned to receive either luspatercept or epoetin alfa. In both treatment arms, best supportive care may be used at the treating clinician’s discretion.

To learn more, please visit the COMMANDS trial page. If you feel that you qualify, please print the clinical trial information and discuss with your oncologist/hematologist.



PEGASUS: A Phase 3 study to evaluate the efficacy and safety of APL-2 in patients with PNH

Have you been diagnosed with Paroxysmal Nocturnal Hemoglobinuria (PNH) and are currently taking eculizumab for your condition?

Interested in learning more about a clinical trial for PNH?

A Phase III trial for patients with PNH is enrolling now! Click on the PEGASUS Study Website link below to learn more. The trial is being conducted at multiple sites in Alberta, Ontario, and Quebec.

Looking for another clinical trial?

AAMAC works with partners to provide ways to participate in clinical trials near you. There are several ways to find clinical trials, including a quick search function provided by Antidote.

Antidote delivers clear, unbiased information about clinical trial options. They aim to match patients to the best trial, regardless of the sponsor. Find their privacy policy here.


AAMAC does not recommend, endorse, or make any representation about the efficacy, appropriateness or suitability of any clinical trial listed on this website.

Pharmaceutical company-sponsored content is highlighted only to give additional information about the trial. All trials are listed on Always seek the advice of your physician or other qualified health care provider with any questions you may have regarding a clinical trial, and never disregard professional medical advice or delay in seeking it because of something you have read on this website.